The evolution of the Regional Economics science through the years. Different levels of geographical space. Personal (subjective) geographic space, mental maps. Maps: their evolution and their constituting elements – Geographic Information Systems (GIS). How do we define ‘region’. Distance as a ‘friction’. The shrinking of space. Call centers, internet auctions, digital divide. The spatial aspect of productive activities: primary, secondary and tertiary sector. The most important schools of thought interpreting the location mechanisms. The spatial distribution of population – determinants of the population’s distribution in space, changes – migration.